Human EDNRB Protein, Flag,His Tag (Detergent)

Cannot supply to this region.

SKU:: EDB-H52D3
Physical State:: Liquid
Molecular Weight:: 61.3 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM HEPES, 150 mM NaCl, DDM, pH7.5, CHS
Immunogen:: EDNRB
Species:: Human
Uniprot:: P24530-1
Synonyms:: Endothelin receptor non-selective type
Extra Details:: Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor with the N-terminus located outside the cell. It's widespread in the human body. EDNRB binds to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum, resulting in the rapid increase of intracellular calcium concentration. Endothelin exerts its biological effects through its receptor (ETR). Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors including malignant melanoma (MM), including promoting tumor growth, anti-apoptosis, promoting angiogenesis and promoting tumor metastasis.