Human E-Cadherin / Cadherin-1 (155-709) Protein, Fc Tag (MALS verified)

Cannot supply to this region.

SKU:: ECD-H5256
Physical State:: Powder
Molecular Weight:: 87.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 20 mM Tris, 150 mM NaCl, pH8.0
Immunogen:: E-Cadherin
Species:: Human
Uniprot:: P12830-1
Synonyms:: CAM 120/80;Epithelial cadherin;Uvomorulin
Extra Details:: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).