Monoclonal Anti-Duocarmycin Antibody, Rabbit IgG (M1E06)

Cannot supply to this region.

SKU:: DUN-MY2287
Physical State:: Powder
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Reactivities:: Rabbit
Buffer:: PBS (pH 7.4)
Immunogen:: Duocarmycin
Clone:: M1E06
Extra Details:: Duocarmycin, a DNA minor groove-binding alkylating agent, acts as a payload in antibody-drug conjugates (ADCs) by selectively targeting AT-rich regions of DNA. It forms covalent bonds with the N3 position of adenine, inducing strand breaks and apoptosis through S-phase cell cycle arrest . This mechanism bypasses multidrug resistance pathways, making it potent against aggressive tumors.