ADC Isotype Control Mouse IgG2a (MMAE)

Cannot supply to this region.

SKU:: DNP-BM487
Physical State:: Powder
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Reactivities:: Mouse
Buffer:: PBS (pH 7.4)
Immunogen:: IgG Control
Clone:: MMAE
Extra Details:: MMAE (Monomethyl auristatin E) is a synthetic microtubule inhibitor. It binds to tubulin to prevent microtubule polymerization, inducing tumor cell cycle arrest and apoptosis. As a highly toxic payload commonly used in ADCs, it has excellent plasma stability; when conjugated to antibodies, it can precisely kill target cells and is widely applied in the R&D of ADC drugs for hematological malignancies and solid tumors.