DD1-M5259
Mouse DDR1 Protein, Fc Tag
Cannot supply to this region.
- SKU:
- DD1-M5259
- Additional Names:
- CD167a
- Physical State:
- Powder
- Molecular Weight:
- 70.2 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- ABP:
- No Import Docs
- Buffer:
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
- Immunogen:
- DDR1
- Species:
- Mouse
- Uniprot:
- Q03146-1
- Synonyms:
- CD167 antigen-like family member A;Cell adhesion kinase;Discoidin receptor tyrosine kinase;Protein-tyrosine kinase MPK-6;Tyrosine kinase DDR;Tyrosine-protein kinase CAK
- Extra Details:
- Discoidin domain receptor 1 (DDR1) is a member of DDRs, which are members of the receptor tyrosine kinase (RTK). Upon collagen binding, DDR1 undergoes tyrosine autophosphorylation, which consequently triggers downstream genetic and cellular pathways and plays critical roles in the regulation of cellular morphogenesis, differentiation, proliferation, adhesion, migration, and invasion. Research shows that DDR1 is closely related to various human diseases including cancer, fibrosis, atherosclerosis, and other inflammatory disorders. New generation DDR1 inhibitors targeting the allosteric sites outside of the canonical ATP-binding pocket or extracellular domain (allosteric inhibitors) may offer a new opportunity for selective DDR1 inhibition therapy development.
- Shipping Conditions:
- Ambient