PE-Labeled Human CTLA-4 / CD152 Protein, His TagStar Staining

Cannot supply to this region.

SKU:: CT4-HP2H3
Physical State:: Powder
Storage Conditions:: Please refer to datasheet
Supplier:: ACRO Biosystems
Buffer:: PBS, 0.2% BSA, pH7.4
Immunogen:: CTLA-4
Species:: Human
Uniprot:: Q6GR94
Synonyms:: Cytotoxic T-lymphocyte-associated antigen 4
Extra Details:: CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.