Biotinylated Human Complement C3 Protein, His,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: CO3-H82E8
Additional Names:: Complement C3|CPAMD1
Physical State:: Powder
Molecular Weight:: 188.5 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: Complement C3
Species:: Human
Uniprot:: P01024-1
Synonyms:: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
Extra Details:: C3 is the major complement component serum. It is mainly synthesized by macrophages and liver. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. It is cleaved into two fragments, C3a and C3b. C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.