Biotinylated Human CLEC4M Protein, Avitag[TM],His Tag (MALS verified)

Cannot supply to this region.

SKU:: CLM-H82Q3
Physical State:: Powder
Molecular Weight:: 41.3 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: CLEC4M
Species:: Human
Uniprot:: Q9H2X3
Synonyms:: C-type lectin domain family 4 member M;CD209 antigen-like protein 1;CD209L;CD299;CD299 antigen;DC-SIGN-related protein;DC-SIGN2;DC-SIGNR;DCSIGNR;dendritic cell-specific ICAM-3-grabbing non-integrin 2;HP10347;L-SIGN;liver/lymph node-specific ICAM-3 grabbing non-integrin;Liver/lymph node-specific ICAM-3-grabbing non-integrin;LSIGN;mannose binding C-type lectin DC-SIGNR
Extra Details:: CLEC4M encodes a C-type lectin receptor crucially involved in cell adhesion and diverse pathogen recognition. This receptor notably binds a wide array of evolutionarily divergent and clinically significant pathogens, including Mycobacterium tuberculosis, as well as viruses such as Ebola, Hepatitis C (HCV), HIV-1, Influenza A, West Nile virus, and the SARS-CoV acute respiratory syndrome coronavirus. Structurally, the protein is organized into four distinct domains: an N-terminal cytoplasmic domain implicated in internalization, a transmembrane region, a flexible tandem-repeat neck domain of variable length, and a C-terminal carbohydrate recognition domain (CRD). CLEC4M shares close sequence and functional homology with the neighboring gene CD209 (DC-SIGN), though they differ in specific viral recognition profiles and tissue expression patterns. CLEC4M exhibits high expression in the endothelial cells of the liver, lymph node, and placenta, and crucially, polymorphisms within its tandem-repeat neck domain have been associated with resistance to SARS infection.

Shipping Conditions:: Ambient