Mouse CLEC5A / MDL-1 Protein, His Tag (MALS & SPR verified)

Cannot supply to this region.

SKU:: CLA-M5243
Physical State:: Powder
Molecular Weight:: 39.9 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: CLEC5A
Species:: Mouse
Uniprot:: Q9R007-3
Synonyms:: C-type lectin superfamily member 5;Myeloid DAP12-associating lectin 1
Extra Details:: CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily.CLEC5A is expressed on monocytes, macrophages, and neutrophils. Its expression is up-regulated on monocytes in rheumatoid arthritis. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.