Mouse Claudin-18.2 Protein, His,Twin-Strep Tag (Detergent)

Cannot supply to this region.

SKU:: CL2-M5585
Physical State:: Liquid
Molecular Weight:: 26.7 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Immunogen:: Claudin-18.2
Species:: Mouse
Uniprot:: P56857-3
Extra Details:: Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.