HEK293/Human APP (GFP) Stable Cell Line

Cannot supply to this region.

SKU:: CHEK-ATP081
Physical State:: Liquid
Storage Conditions:: Liquid N2
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Immunogen:: APP
Species:: Human
Extra Details:: Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. The majority of APP is cleaved at the plasma membrane by the A Alpha-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with B Beta-secretase cleavage by BACE1 on the N-terminal part of the AB Beta domain, releasing sAPPB Beta from a membrane-anchored fragment named B BetaCTF or C103, which is subsequently cleaved by G Gamma-secretase to release AB Beta.