Biotinylated Rat Complement Factor B Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: CFB-R82Q3
Physical State:: Powder
Molecular Weight:: 86.7 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Complement Factor B
Species:: Rat
Uniprot:: Q6MG74
Synonyms:: B-factor, properdin;Bf;complement factor B;Da1-24;properdin factor B
Extra Details:: Complement factor B is a component of the alternative pathway (AP) of complement activation. Factor B is one of the upstream, proximal components unique to the AP and is essential for the activation of the pathway. It is an integral component that drives the amplification loop. It is cleaved by factor D into two fragments: Ba and Bb. Bb, a serine protease, then combines with C3b to form the AP C3 convertase (and, upon binding additional C3b, the C5 convertase). Bb has also been implicated in the proliferation and differentiation of preactivated B-lymphocytes and the stimulation of lymphocyte blastogenesis. In contrast, Ba inhibits the proliferation of preactivated B-lymphocytes and mediates the rapid spreading of peripheral blood monocytes. Through the convertases, factor B ultimately contributes to effector functions such as the lysis of erythrocytes.