Biotinylated Mouse CD27 Ligand / CD70 Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: CDL-M82QB
Additional Names:: CD27L|CD27LG|CD70|TNFSF7|TNFSF7G
Physical State:: Powder
Molecular Weight:: 20.1 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: CD27 Ligand
Species:: Mouse
Uniprot:: O55237-1
Synonyms:: CD27 ligand;Tumor necrosis factor ligand superfamily member 7
Extra Details:: Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNG Gamma production, on NK cells.