Biotinylated Human CD3 epsilon Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: CDE-H82E1
Additional Names:: CD3-epsilon|CD3E|FLJ18683|T3E|TCRE
Physical State:: Powder
Molecular Weight:: 15.5 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: CD3 epsilon
Species:: Human
Uniprot:: P07766-1
Synonyms:: T-cell surface antigen T3/Leu-4 epsilon chain
Extra Details:: CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.