Cynomolgus CD3 epsilon Protein, Fc,His Tag (MALS verified)

Cannot supply to this region.

SKU:: CDE-C5254
Additional Names:: CD3-epsilon|CD3E|FLJ18683|T3E|TCRE
Physical State:: Powder
Molecular Weight:: 38.3 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: Tris with Glycine, Arginine and NaCl, pH7.5
Immunogen:: CD3 epsilon
Species:: Non-human Primate
Uniprot:: Q95LI5
Synonyms:: CD3 epsilon FN18-;CD3 epsilon FN18+;CD3e molecule, epsilon (CD3-TCR complex);T-cell surface glycoprotein CD3 epsilon chain
Extra Details:: CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.