Human Fc gamma RIIB/C (CD32b/c) Protein, Strep Tag (MALS & SPR verified)

Cannot supply to this region.

SKU:: CDB-H5284
Physical State:: Powder
Molecular Weight:: 22.7 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Fc gamma RIIB/C / CD32b/c
Species:: Human
Uniprot:: P31994-1
Synonyms:: CDw32;Fc-gamma RII-b
Extra Details:: Receptors for the Fc region of IgG (Fc G Gamma R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc G Gamma Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human FcG Gamma RII /CD32 (A, B, and C) and one for mouse FcG Gamma RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.