Rhesus macaque Fc gamma RIIA / CD32a Protein, His Tag (SPR & MALS verified)

Cannot supply to this region.

SKU:: CDA-R52H4
Additional Names:: CD32|CD32a|FCG2|FCGR2A|FCGR2A1|IGFR2
Physical State:: Powder
Molecular Weight:: 22.3 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Fc gamma RIIA / CD32a
Species:: Non-human Primate
Extra Details:: Receptors for the Fc region of IgG (Fc G Gamma R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc G Gamma Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human FcG Gamma RII /CD32 (A, B, and C) and one for mouse FcG Gamma RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIM-bearing receptors may also be coexpressed and co-engaged by specific ligands. CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.