CD9-H5253
Human CD39 Protein, Mouse IgG2a Fc Tag (active enzyme)
Cannot supply to this region.
- SKU:
- CD9-H5253
- Additional Names:
- CD39|Ecto-ATPase 1|Ecto-ATPDase 1|ENTPD1|NTPDase 1
- Physical State:
- Liquid
- Molecular Weight:
- 77.3 kda
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 20 mM Tris, 500 mM Arginine, 150 mM NaCl, pH7.5
- Immunogen:
- CD39
- Species:
- Human
- Uniprot:
- P49961-1
- Synonyms:
- Ecto-apyrase;Ecto-ATP diphosphohydrolase 1;Lymphoid cell activation antigen
- Extra Details:
- CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.
- Shipping Conditions:
- Dry Ice