Human CD117 / c-kit Protein, Fc Tag (MALS verified)

Cannot supply to this region.

SKU:: CD7-H525B
Physical State:: Powder
Molecular Weight:: 50.2 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: CD117
Species:: Human
Uniprot:: P10721-2
Synonyms:: p145 c-kit;Piebald trait protein;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Extra Details:: c-KIT activation has been shown to have oncogenic activity in gastrointestinal stromal tumors (GISTs), melanomas, lung cancer, and other tumor types. The targeted therapeutics nilotinib and sunitinib have shown efficacy in treating KIT overactive patients, and are in late-stage trials in melanoma and GIST. KIT overactivity can be the result of many genomic events from genomic amplification to overexpression to missense mutations. Missense mutations have been shown to be key players in mediating clinical response and acquired resistance in patients being treated with these targeted therapeutics.