Biotinylated Human B7-2 / CD86 Protein, Fc,Avitag[TM], premium grade

Cannot supply to this region.

SKU:: CD6-H82F5
Additional Names:: B7-2|B70|CD28LG2|CD86|LAB72|MGC34413
Physical State:: Powder
Molecular Weight:: 53.8 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Immunogen:: B7-2
Species:: Human
Uniprot:: P42081
Synonyms:: Activation B7-2 antigen;B-lymphocyte activation antigen B7-2;B7-2;B7.2;B70;BU63;CD28LG2;CD86 antigen (CD28 antigen ligand 2, B7-2 antigen);CTLA-4 counter-receptor B7.2;FUN-1;LAB72;T-lymphocyte activation antigen CD86
Extra Details:: Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon G Gamma. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-K KappaB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.

Shipping Conditions:: Ambient