Human CD206 / MMR Protein, His Tag, low endotoxin (MALS verified)

Cannot supply to this region.

SKU:: CD6-H52H9
Additional Names:: CD206|CLEC13D|CLEC13DL|hMR|MMR|MRC1|MRC1L1
Physical State:: Powder
Molecular Weight:: 158.6 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: CD206
Species:: Human
Uniprot:: P22897-1
Synonyms:: C-type lectin domain family 13 member D;C-type lectin domain family 13 member D-like;Human mannose receptor;Macrophage mannose receptor 1-like protein 1
Extra Details:: Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.