CD3-H5252
Human CD73 Protein, Mouse IgG2a Fc Tag (active enzyme)
Cannot supply to this region.
- SKU:
- CD3-H5252
- Additional Names:
- 5'-NT|5'-Nucleotidase|CD73|NT5|NT5E|NTE
- Physical State:
- Powder
- Molecular Weight:
- 84.9 kda
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
- Immunogen:
- CD73
- Species:
- Human
- Uniprot:
- P21589-1
- Synonyms:
- Ecto-5'-nucleotidase
- Extra Details:
- 5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.
- Shipping Conditions:
- Ambient