Canine CD73 / NT5E Protein, His Tag (MALS verified) (active enzyme)

Cannot supply to this region.

SKU:: CD3-C52H5
Additional Names:: 5'-NT|5'-Nucleotidase|CD73|NT5|NT5E|NTE
Physical State:: Powder
Molecular Weight:: 59.8 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 20 mM Tris, 120mM NaCl, pH7.5
Immunogen:: CD73
Species:: Canine
Extra Details:: 5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.