Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc Tag

Cannot supply to this region.

SKU:: CD2-H5257
Additional Names:: CD112|Nectin-2|PVRL2
Physical State:: Powder
Molecular Weight:: 62.4 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: Tris with Glycine, Arginine and NaCl, pH7.5
Immunogen:: Nectin-2
Species:: Human
Uniprot:: Q92692-2
Synonyms:: Herpes virus entry mediator B;Nectin cell adhesion molecule 2;Poliovirus receptor-related protein 2
Extra Details:: Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).