Human IL-3 R Beta / CD131 Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: CD1-H52H8
Physical State:: Powder
Molecular Weight:: 50.6 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: CD131
Species:: Human
Uniprot:: P32927-1
Synonyms:: CDw131;GM-CSF/IL-3/IL-5 receptor common beta subunit
Extra Details:: CD131- the common B Beta Subunit, is a member of the type 1 cytokine receptor family. There are three major classes of heteroreceptor complexes, where the receptor complex utilises a common shared receptor subunit as a signal-transducing chain along with a cytokine specific subunit. These three classes include those which use gp130, those which use G Gammac and those which use the common B Beta subunit, B Betac(CD131). CD131 is shared by three of the "four-helical bundle" family of cytokines; IL-3, IL-5 and GM-CSF, and forms a receptor complex along with a cytokine specific A Alpha chain for each of these cytokines.Moreover, even though each of these cytokines have their own specific A Alpha subunit, the co-utilisation of CD131 suggests a common intra-cellular process of both unique and/or overlapping activities on expressing cells.