Mouse B7-1 / CD80 Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: CD0-M5228
Additional Names:: B7|B7-1|B7.1|BB1|CD28LG|CD28LG1|CD80|LAB7
Physical State:: Powder
Molecular Weight:: 25.6 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: B7-1
Species:: Mouse
Uniprot:: Q00609-1
Synonyms:: Activation B7-1 antigen
Extra Details:: B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-K KappaB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.