Human CCL21 Protein, His Tag

Cannot supply to this region.

SKU:: CC1-H55H3
Physical State:: Powder
Molecular Weight:: 14.1 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: CCL21
Species:: Human
Uniprot:: O00585
Synonyms:: 6Ckine;beta chemokine exodus-2;Beta-chemokine exodus-2;C-C motif chemokine 21;chemokine (C-C motif) ligand 21;CKb9;ECL;Efficient Chemoattractant for Lymphocytes;SCYA21;secondary lymphoid tissue chemokine;Secondary lymphoid-tissue chemokine;SLC;small inducible cytokine subfamily A (Cys-Cys), member 21;Small-inducible cytokine A21;TCA4
Extra Details:: CC chemokine 21 (CCL21), also known as secondary lymphoidorgan chemokine (SLC), is a ligand for the chemokine receptor CCR7. CCL19 and CCL21 are the only ligands for CCR7, which is expressed by various subsets of immune cells. CCL19 and CCL21 function to recruit CCR7 expressing antigen presenting cells, like dendritic cells and naive T-cells, to the lymph nodes. CCL21 seems to be the critical CCR7 ligand regulating dendritic cell homeostasis and function. CCL21 has an unusual extended C-terminal tail for a chemokine. Only one gene exists for this chemokine in human beings, whereas mice have two. CCL21 Inhibit hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells.