Human Cadherin-11 Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: CA1-H52H3
Physical State:: Powder
Molecular Weight:: 63.8 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS, 0.5 M Arginine, pH7.4
Immunogen:: Cadherin-11
Species:: Human
Uniprot:: P55287-1
Synonyms:: OSF-4;Osteoblast cadherin
Extra Details:: Cadherin-11 is a type II cadherin which mediates cell-to-cell homophilic interactions. Cadherin-11 is mainly expressed on mesenchymal cells and is essential for tissue migration and organization during embryogenesis, while its expression on epithelial cancer cells is implicated in tumor progression and metastasis suggesting a potential role in the epithelial-to-mesenchymal transition phenomenon. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. In addition, cadherin-11 has been shown to increase the invasive capacity of Fibroblast-like Synoviocytes (FLS) and consequently be involved in the formation of the rheumatoid pannus.