Human Caspase-1 Protein, His Tag&Tag Free

Cannot supply to this region.

SKU:: CA1-H51W3
Physical State:: Liquid
Molecular Weight:: 21.9 kDa & 10.4 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: 20 mM Tris, 300 mM NaCl, 0.5 M Arginine, pH8.0
Immunogen:: Caspase-1
Species:: Human
Uniprot:: P29466-1
Synonyms:: Interleukin-1 beta convertase;Interleukin-1 beta-converting enzyme;p45
Extra Details:: Caspases are an evolutionary conserved family of cysteine-dependent proteases that are involved in many vital cellular processes including apoptosis, proliferation, differentiation and inflammatory response. Dysregulation of caspase-mediated apoptosis and inflammation has been linked to the pathogenesis of various diseases such as inflammatory diseases, neurological disorders, metabolic diseases, and cancer.The members of the caspase family are grouped based on their functional contribution in inflammation (caspases-1, -4, -5, and -11) and involvement in cell death (initiation: caspases-2, -8, -9, and -10; execution: caspases-3, -6, and -7) or by their consensus recognition sequences. Inflammatory caspases recognize the sequence Trp-Glu-His-Asp and are classified as group I. Whilst group II and group III recognize Asp-Glu-X-Asp and (Leu/Val)-Glu-X-Asp, respectively.