C5A-H5116
Human Complement C5a Protein, Tag Free
Cannot supply to this region.
- SKU:
- C5A-H5116
- Additional Names:
- C5a|Complement Component 5a
- Physical State:
- Powder
- Molecular Weight:
- 8.3 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- ABP:
- No Import Docs
- Buffer:
- PBS
- Immunogen:
- Complement C5a
- Species:
- Human
- Uniprot:
- P01031
- Synonyms:
- anaphylatoxin C5a analog;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4;C5a;C5a anaphylatoxin;C5b;C5D;complement C5;complement component 5;CPAMD4;ECLZB;prepro-C5
- Extra Details:
- Complement component C5a (C5a) is a protein fragment generated upon cleavage of complement component C5. It is a potent chemotactic factor for human peripheral blood neutrophils and monocytes and is believed to play an important role in a number of inflammatory conditions. The major functions of C5a are as follows: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is an effective leukocyte chemoattractant, promoting the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing integrin avidity and upregulating the lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator and appears to be a key factor in the pathogenesis of many inflammatory diseases involving the complement system; and C5a modulates the balance between activating and inhibitory IgG Fc receptors on leukocytes, a mechanism that may enhance autoimmune responses under pathological conditions.
- Shipping Conditions:
- Ambient