Human C5AR1 Full Length Protein (VLP)

Cannot supply to this region.

SKU:: C51-H52P4
Physical State:: Liquid
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS, Arginine, pH7.4
Immunogen:: C5AR1
Species:: Human
Uniprot:: P21730-1
Synonyms:: C5a anaphylatoxin chemotactic receptor
Extra Details:: Complement Component 5a Receptor 1 (C5aR1), also known as CD88, is a high-affinity G protein-coupled receptor (GPCR) essential for mediating potent inflammatory responses. In the tumor microenvironment, C5aR1 activation on myeloid-derived suppressor cells (MDSCs) facilitates immune evasion and metastasis. Crucially, C5aR1 interacts with glycosaminoglycans (GAGs), such as heparin, which act as co-receptors or modulators. These C5aR1-GAG interactions influence ligand recruitment and receptor signaling, making this axis a prime target for developing therapeutic antibodies and small-molecule inhibitors in oncology and autoimmune disorders.