Mouse BAFFR / TNFRSF13C Protein, Fc Tag (MALS verified)

Cannot supply to this region.

SKU:: BAR-M5259
Additional Names:: BAFF-R|BAFFR|BROMIX|CD268|CVID4|prolixin|TNFRSF13C
Physical State:: Powder
Molecular Weight:: 33.3 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: Tris with Glycine, Arginine and NaCl, pH7.5
Immunogen:: BAFFR
Species:: Mouse
Extra Details:: BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.