Biotinylated Human B7-H6 / NCR3LG1 Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: B76-H82E5
Additional Names:: B7 Homolog 6|B7-H6|NCR3LG1
Physical State:: Powder
Molecular Weight:: 30.4 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: B7-H6
Species:: Human
Uniprot:: Q68D85-1
Synonyms:: B7 homolog 6
Extra Details:: The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.