APP-H52H5
Human APP / SAPPbeta Protein, His Tag (MALS verified)
Cannot supply to this region.
- SKU:
- APP-H52H5
- Additional Names:
- ABPP|Amyloid-beta A4 protein|APPI
- Physical State:
- Powder
- Molecular Weight:
- 73.8 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- ABP:
- No Import Docs
- Buffer:
- PBS, 0.3 M Arginine, pH7.4
- Immunogen:
- APP
- Species:
- Human
- Uniprot:
- P05067-8
- Synonyms:
- ABPP;Alzheimer disease amyloid protein;Amyloid precursor protein;Amyloid-beta precursor protein;APPI;Cerebral vascular amyloid peptide;PreA4;Protease nexin-II
- Extra Details:
- Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770. The majority of APP is cleaved at the plasma membrane by the A Alpha-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with B Beta-secretase cleavage by BACE1 on the N-terminal part of the AB Beta domain, releasing sAPPB Beta from a membrane-anchored fragment named B BetaCTF or C99, which is subsequently cleaved by G Gamma-secretase to release AB Beta.
- Shipping Conditions:
- Ambient