Human Angiotensinogen Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: ANN-H5243
Physical State:: Powder
Molecular Weight:: 51.6 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Angiotensinogen
Species:: Human
Uniprot:: P01019-1
Synonyms:: Serpin A8
Extra Details:: The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.