Human Angiogenin / RNASE5 Protein, His Tag (SPR verified)

Cannot supply to this region.

SKU:: ANN-H5149
Physical State:: Powder
Molecular Weight:: 16.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Angiogenin
Species:: Human
Uniprot:: P03950-1
Synonyms:: Ribonuclease 5
Extra Details:: Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo