Alexa Fluor[TM] 488-Labeled Human Alpha-Synuclein Pre-formed Fibrils Protein, Tag Free

Cannot supply to this region.

SKU:: ALN-HA114
Physical State:: Liquid
Molecular Weight:: 14.5 kda
Storage Conditions:: -70[o]C Avoid freeze/thaw cycles. Protect from light.
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Alpha-Synuclein
Species:: Human
Uniprot:: P37840-1
Synonyms:: Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor
Extra Details:: Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.