Human Alpha-Synuclein Protein, His Tag, low endotoxin

Cannot supply to this region.

SKU:: ALN-H52H8
Additional Names:: alpha-Synuclein|NACP|PARK1|SNCA
Physical State:: Powder
Molecular Weight:: 16.3 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 100 mM NaAC, pH7.0
Immunogen:: Alpha-Synuclein
Species:: Human
Uniprot:: P37840-1
Synonyms:: Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor
Extra Details:: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.