ALN-H5117
Human Alpha-Synuclein (E46K) Protein, Tag Free
Cannot supply to this region.
- SKU:
- ALN-H5117
- Physical State:
- Liquid
- Molecular Weight:
- 14.5 kda
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- ABP:
- No Import Docs
- Buffer:
- 50mM HEPES, 100mM NaCl, pH8.0
- Immunogen:
- Alpha-Synuclein
- Species:
- Human
- Uniprot:
- P37840-1
- Synonyms:
- Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor
- Extra Details:
- Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
- Shipping Conditions:
- Dry Ice