AD9-H52H7
Human ADAM9 Protein, His Tag (active enzyme, HPLC verified)
Cannot supply to this region.
- SKU:
- AD9-H52H7
- Additional Names:
- ADAM9|cysteine-rich protein 9|disintegrin|Disintegrin and metalloproteinase domain-containing protein 9 (EC:3.4.24.-) Cellular disintegrin-related protein|KIAA0021|MCMP|MDC9|Meltrin-gamma|Metalloprotease|MLTNG|Myeloma cell metalloproteinase
- Physical State:
- Liquid
- Molecular Weight:
- 55.2 kDa
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 20 mM Tris, 500 mM NaCl, pH7.5
- Immunogen:
- ADAM9
- Species:
- Human
- Uniprot:
- Q13443-1
- Synonyms:
- Cellular disintegrin-related protein;Meltrin-gamma;Metalloprotease/disintegrin/cysteine-rich protein 9;Myeloma cell metalloproteinase
- Extra Details:
- ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin domain for adhesion and the metalloprotease domain for ectodomain shedding of a wide variety of cell surface proteins. ADAM9 influences the developmental process, inflammation, and degenerative diseases.Recently, increasing evidence has shown that ADAM9 plays an important role in tumor biology. Overexpression of ADAM9 has been found in several cancer types and is correlated with tumoraggressiveness and poor prognosis. In addition, through either proteolytic or non-proteolytic pathways, ADAM9 promotes tumor progression, therapeutic resistance, and metastasis of cancers.Therefore, comprehensively understanding the mechanism of ADAM9 is crucial for the development of therapeutic anti-cancer strategies. In this review, we summarize the current understanding of ADAM9 in biological function, pathophysiological diseases, and various cancers. Recent advances in therapeutic strategies using ADAM9-related pathways are presented as well.
- Shipping Conditions:
- Dry Ice