Mouse ADAM17 / TACE / CD156b Protein, His Tag

Cannot supply to this region.

SKU:: AD7-M52H1
Additional Names:: ADAM17|CD156b|TACE
Physical State:: Powder
Molecular Weight:: 63.4 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM MES, 150 mM NaCl, pH6.5
Immunogen:: ADAM17
Species:: Mouse
Uniprot:: Q9Z0F8
Synonyms:: CD156b;disintegrin and metalloproteinase domain-containing protein 17;Tac;Tace;TNF-alpha convertase;TNF-alpha converting enzyme;TNF-alpha-converting enzyme
Extra Details:: Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.