PerCP-Cy5.5 Conjugated Anti-CD79a Monoclonal Antibody (Clone:HM47)

Size

£741.00

SKU:: 30-1528PC-Cy5.5
Additional Names:: CD79A||IGA||MB1
Purification:: Purified antibody is conjugated with activated tandem dye of activated Peridinin-Chlorophyll Protein-Cyanine 5.5 (PerCP-Cy5.5) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Storage Conditions:: Store at 2-8[o]C protected from light. Do not freeze.
Supplier:: Abeomics Inc.
Host:: Mouse
Reactivities:: Human
Immunogen:: Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
Clone:: HM47
Extra Details:: CD79a (Ig alpha; MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs); and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently; in pre-B cells; CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage; CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn; which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.