PerCP-Cy5.5 Conjugated Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-229)

Size

£741.00

SKU:: 30-1313PC-Cy5.5
Additional Names:: ENG||END||Endoglin||HHT1||ORW1
Purification:: Purified antibody is conjugated with activated tandem dye of activated Peridinin-Chlorophyll Protein-Cyanine 5.5 (PerCP-Cy5.5) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Storage Conditions:: Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
Supplier:: Abeomics Inc.
Host:: Mouse
Reactivities:: Human
Immunogen:: Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
Clone:: MEM-229
Extra Details:: CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing; infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. Specificity: The antibody MEM-229 recognizes an extracellular epitope of CD105 (Endoglin); a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels); activated monocytes and tissue macrophages; stromal cells of certain tissues including bone marrow; pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Shipping Conditions:: Blue Ice