Polyclonal Antibody to E Cadherin

Size

£319.00

SKU:: 11-7545
Additional Names:: CDH1||CDHE||UVO
Purification:: Protein A Chromatography
Supplier:: Abeomics Inc.
Host:: Rabbit
Reactivities:: Human
Uniprot:: P12830
Gene Details:: CDH1
Extra Details:: E-cadherin is a calcium-regulated adhesion molecule expressed in most normal epithelial tissues. It is localized on the surfaces of epithelial cells in regions of cell-cell contact known as adherens junctions. The E-cadherin gene is located on chromosome 16q22.1. E-cadherin is associated with gland formation, stratification, and epithelial polarization. Besides its role in normal cells, this highly conserved gene can play a major role in malignant cell transformation, and especially in tumor development and progression. Selective loss of E-cadherin can cause dedifferentiation and invasiveness in human carcinomas, leading E-cadherin to be classified as a tumor suppressor.