Polyclonal Antibody to BRD4, HUNK1

Size

£319.00

SKU:: 11-7501
Additional Names:: BRD4||HUNK1
Purification:: Protein A Chromatography
Supplier:: Abeomics Inc.
Host:: Rabbit
Reactivities:: Human
Uniprot:: O60885
Gene Details:: BRD4
Extra Details:: BRD4 is a member of the BET (bromo domain and extra terminal domain) family, along with BRD2, BRD3 and BRDT. BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. A chromosomal aberration involving BRD4 is found in a rare, aggressive and lethal carcinoma arising in midline organs of young people. It expressed ubiquitously and has three isoforms. Isoform B acts as a chromatin insulator in the DNA damage response pathway.