11-4036
Polyclonal Antibody to IL-37
Size
£319.00
- SKU:
- 11-4036
- Additional Names:
- IL37||FIL1Z||IL1F7||IL1H4||IL1RP1
- Purification:
- Protein A Chromatography
- Supplier:
- Abeomics Inc.
- Host:
- Rabbit
- Reactivities:
- Human
- Uniprot:
- Q9NZH6
- Gene Details:
- IL37
- Extra Details:
- IL-37 (Interleukin-37) is a member of IL-1 family and is primarily an anti-inflammatory cytokine, which reduces systemic and local inflammation. There are five different splice variants of IL-37 termed IL-37a-e, where Isoform IL-37b is the largest isoform. IL-37 has significant sequence similarity with IL-18 and highly expressed in inflammatory tissues, which inhibits the excessive inflammatory response. The expression is highly induced by several toll-like receptor (TLR) ligands and pro-inflammatory cytokines such as IL-1beta, TNF-alpha, IFN-gamma. IL-37 is a potent inhibitor of innate immunity by shifting the cytokine equilibrium away from excessive inflammation.
- Shipping Conditions:
- Blue Ice