Polyclonal Antibody to TxNIP/VDUP1

Size

£319.00

SKU:: 11-3023
Additional Names:: TXNIP||VDUP1
Purification:: Protein A Chromatography
Supplier:: Abeomics Inc.
Host:: Rabbit
Reactivities:: Human
Uniprot:: Q9H3M7
Gene Details:: TXNIP
Extra Details:: TXNIP (thioredoxin interacting protein) inhibits thioredoxin activity by limiting its bioavailability in response to oxidative stress. TXNIP restores COPS5-induced suppression of CDKN1B stability by interacting with COPS5 and blocks the COPS5-mediated translocation of CDKN1B from nucleus to the cytoplasm. TXNIP functions as a transcriptional repressor. TXNIP has been reported to be a suppressor of tumor cell growth and inhibits the proteasomal degradation of DDIT4, contributing to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). TXNIP is expresed in adipose tissue, adrenal cortex, adrenal gland, amniotic fluid and amygdale.