Monoclonal Antibody to IDH1 (Clone: ABM44B3)

Size

£319.00

SKU:: 10-7551
Additional Names:: IDH1||PICD
Purification:: Protein G Chromatography
Supplier:: Abeomics Inc.
Host:: Mouse
Reactivities:: Human
Clone:: ABM44B3
Uniprot:: O75874
Gene Details:: IDH1
Extra Details:: Isocitrate dehydrogenase 1 (IDH1) is a dimeric cytosolic NADP-dependent dehydrogenase that catalyzes decarboxylation of isocitrate into alpha-ketoglutarate. It belongs to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). It serves a significant role in cytoplasmic NADPH production. It is found in the cytoplasm and peroxisomes. IDH1 is of great importance in cell metabolism and energy conversion. Mutations in IDH1 are found in a somatic mosaic fashion in patients with multiple enchondromas.