Monoclonal antibody to CD207 (Langerin) (Clone: 10E2)

Size

£452.00

SKU:: 10-4900
Additional Names:: Langerin, C-type lectin domain family 4 member K, CLEC4K
Purification:: Affinity chromatography.
Supplier:: Abeomics Inc.
Host:: Mouse
Reactivities:: Human
Clone:: 10E2
Uniprot:: Q9UJ71
Gene Details:: CD207
Extra Details:: CD207, also known as Langerin, is a 40 kD type II transmemberane cell glycoprotein which belongs to C-type lectin with mannose binding specificity. It is predominantly expressed on Langerhans cells and induces the formation of Birbeck granules, the Langerhans cell hallmark organelle. It is also found on several other subtypes of dendritic cells, such as dermal CD103-positive dendritic cells and splenic CD8-positive dendritic cells. Langerin is generally thought to be involved in antigen processing. Recently, it has been found that HIV captured by Langerin was internalized into Birbeck granule and degraded, which results in inhibition of HIV-1 infection and subsequent transmission.