Monoclonal antibody to CD16 (Clone: B73.1)

Size

£319.00

SKU:: 10-4206
Additional Names:: CD16-II, CD16a antigen, Fc-gamma RIII-alpha, FcR-10, IgG Fc receptor III-2, CD16A, FCG3, FCGR3, IGFR3
Application:: IF
Purification:: Protein G Chromatography
Supplier:: Abeomics Inc.
Host:: Mouse
Reactivities:: Human, Mouse
Clone:: B73.1
Uniprot:: P08637
Gene Details:: FCGR3A
Extra Details:: CD16, also known as low affinity IgG receptor III (FcgammaRIII), is expressed as two distinct forms, referred to as CD16a and CD16b. CD16a (FcgammaRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein expressed on the surface of NK cells, activated monocytes, macrophages, a subset of T cells, and placental trophoblasts in humans. CD16b (FcgammaRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein whose extracellular domain is over 95% homologous to that of CD16a, and is expressed specifically on neutrophils. CD16 binds to aggregated IgG or IgG-antigen complex, which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).